PolysacDB Lipoarabinomannan 1655

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipoarabinomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium leprae

[edit] Basic Structure

Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate

[edit] Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

[edit] Antigenic Nature used to produce antibodies

a combination of M. leprae 30KS and 1OKP

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab A12C

[edit] Antibody type and class

IgG1

[edit] Assay System

ELISA, immunoblotting

[edit] Cross-reactivity

This Mab was specific for M. leprae LAM

[edit] Proposed epitopes

α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope

[edit] Proposed Utility

This Mab would help in the structure elucidation of lipoarabinomanna

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database