PolysacDB Lipooligosaccharide 1626

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipooligosaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Moraxella catarrhalis serotype A

Basic Structure

LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo

Proposed functions

Moracella lipooligosaccharide is a potential virulence factor

Antigenic Nature used to produce antibodies

heat inactivated Moraxella catarrhalis serotype A

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 217H4

Antibody type and class

IgG3

Assay System

ELISA, bactericidal assays and immunofluorescence assay

Cross-reactivity

This Mab was specific to serotype A

Proposed epitopes

N/A

Proposed Utility

This Mab could be useful for the detection of M. catarrhalis and its LOS antigen in clinical samples

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database