PolysacDB Lipooligosaccharide 1619

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipooligosaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Moraxella catarrhalis serotype C

Basic Structure

LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to β-D-Galp-(1-->4)-α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-α-Kdop [branched to Kdop-(2-->4)]

Proposed functions

Moracella lipooligosaccharide is a potential virulence factor

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

N/A

Assay System

ELISA and immunoblotting

Cross-reactivity

This antisera cross-reacted with Serotype A LPS

Proposed epitopes

A terminal β-D-Gal-(1-->4)-α-D-GlcNA seemed to be a part of the epitope

Proposed Utility

This antisera may help in sertotyping of moraxella strains

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database