PolysacDB Capsular polysaccharide 1573

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Meningococci strain P355 (group B]

Basic Structure

It is a homopolymer of α(2-->8) sialic acid

Proposed functions

This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins

Antigenic Nature used to produce antibodies

Viable meningococci strain P355 (group B]

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 2-2-B

Antibody type and class

IgM

Assay System

Quantitative precipitation analysis, Antigen-binding assay

Cross-reactivity

N/A

Proposed epitopes

N/A

Proposed Utility

This Mab was bactericidal with human C strain and opsonized K1 polysaccharide containing E. coli in an opsonophagocytic assay with human C strain

Weblink

PubMed

External Links

• Link to PolysacDB database