PolysacDB Lipopolysaccharide 1516

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Klebsiella pneumoniae Friedlander 201

Basic Structure

O-1 side chain of the LPS is proposed to contain a disaccharide repeat unit consisting of [-α-D-Galp-(1->3)-β-D-Galf-] (1->4), where Gal is galactose

Proposed functions

These major cell surface antigens play important roles in the ability of the bacterium to evade host cell defenses

Antigenic Nature used to produce antibodies

formalinized whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab Ru-O1

Antibody type and class

IgG2b

Assay System

ELISA and invivo protection studies

Cross-reactivity

This Mab cross-reacted with LPS prepared from strains belonging to the O1 serogroup, O19b antigen of E. coli, which has been shown to be immunologically identical to Klebsiella O1 and O6 and O8 antigens

Proposed epitopes

O1 antigen seems to bea part of the epitope

Proposed Utility

This Mab showed invivo protection and significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations

Weblink

PubMed Central

External Links

• Link to PolysacDB database