PolysacDB Capsular polysaccharide 1497

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Cryptococcus neoformans Serotype A [strain 24064]

[edit] Basic Structure

The major component of C. neoformans capsular polysaccharide is glucurunoxylomannan [GXM] consisting of an unbranched mannose backbone substituted with xylose, glucuronic acid and O-acetyl residues

[edit] Proposed functions

The major component of C. neoformans capsular polysaccharide is glucurunoxylomannan [GXM] consisting of an unbranched mannose backbone substituted with xylose, glucuronic acid and O-acetyl residues

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 5E9

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody reacted with 2 serotype A strains 24064 and 371

[edit] Proposed epitopes

Mab 5E9 bound to de-O-acetylated GXM of strain 371 but not of strain 24064. This shows the probable epitope to be variable among strains and to be acetylation independent

[edit] Proposed Utility

N/A

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database