PolysacDB Heptasaccharide motif (M2) of Glucurunoxylomannan 1491

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Heptasaccharide motif (M2) of Glucurunoxylomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Cryptococcus neoformans Serotype D [strain 24067]

Basic Structure

The heptasaccharide consists of two M2 triad repeats and mannose residue. The M2 repeat was selected because it is commonly found in GXM of serotype A strain

Proposed functions

Glucurunoxylomannan is an antiphagocytic determinant ; an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Human serum albumin

Conjugation Method

N/A

Antibodies

Mab 3F10

Antibody type and class

IgM

Assay System

Immunofluorescence and phagocytosis assays

Cross-reactivity

This antibody cross-reacted with Serotype D

Proposed epitopes

N/A

Proposed Utility

N/A

Weblink

PubMed

External Links

• Link to PolysacDB database