PolysacDB Lipopolysaccharide 1459

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Haemophilus ducreyi

Basic Structure

It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues

Proposed functions

LPS plays an important role in the infection process

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MAHD7

Antibody type and class

IgM

Assay System

ELISA and immunoblotting

Cross-reactivity

It reacts with all H. ducreyi strains

Proposed epitopes

MAb MAHD7 recognizes the common conserved inner core region of the LOS

Proposed Utility

This Mab would aid in the classification of H. ducreyi for epidemiological purposes

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database