PolysacDB Lipopolysaccharide 1453

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Francisella tularensis

Basic Structure

The O-antigen consisted of the following residues : -2)βD-Quip4NFo(1-->4)α-D-GalpNAcA6NH2(1-->4)α-D-GalpNAcA6NH2(1-->3)βDQuipNAc(1-

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

heat-killed F. tularensis

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab FT14

Antibody type and class

IgM

Assay System

ELISA and immunoblotting

Cross-reactivity

This Mab was unique to F. tularensis

Proposed epitopes

O-side chains seems to be an important part of the epitope

Proposed Utility

This Mab would help to detect the organism in environmental samples and clinical specimens

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database