PolysacDB Lipopolysaccharide 1362

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Chlamydia trachomatis serotype F

[edit] Basic Structure

The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)

[edit] Proposed functions

LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin

[edit] Antigenic Nature used to produce antibodies

elementary bodies of Chlamydia trachomatis serotype F

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab F1-A6

[edit] Antibody type and class

IgG2b

[edit] Assay System

IFT assay, ELISA

[edit] Cross-reactivity

This antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci

[edit] Proposed epitopes

The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)

[edit] Proposed Utility

This Mab can be used in the epitope characterization of Chlamydial LPS

[edit] Weblink

PubMed Central

[edit] External Links

• IEDB Epitopic Detail

• Link to PolysacDB database