PolysacDB Lipopolysaccharide 1358

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Chlamydia trachomatis serotype E

Basic Structure

The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)

Proposed functions

LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin

Antigenic Nature used to produce antibodies

elementary bodies of Chlamydia trachomatis serotype E

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab EV1-H1

Antibody type and class

IgG2a

Assay System

IFT assay, ELISA

Cross-reactivity

This antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci

Proposed epitopes

The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)

Proposed Utility

This Mab can be used in the epitope characterization of Chlamydial LPS

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database