PolysacDB O-polysaccharide 1259

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Campylobacter fetus 554

Basic Structure

The LPS molecule of C. fetus is composed of three distinct structural domains: a hydrophobic lipid A portion which forms the outer leaflet of the outer membrane and which contains the endotoxic activity, a low-molecular-weight oligosaccharide core complex, and a variable-length O-specific polysaccharide chain with repeating oligosaccharide units (O-antigen)

Proposed functions

The LPS O-antigens are the basis of the C. fetus heat-stable serotyping Scheme

Antigenic Nature used to produce antibodies

a mixture (1:1) of C. fetus 553 and 554 formalin-killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab M1177

Antibody type and class

IgG1

Assay System

Indirect ELISA, immunoblotting,

Cross-reactivity

This antibody was specific to O antigen of C. fetus 554 and did not cross-react with C. fetus 553

Proposed epitopes

Acetylated groups seem to be an important part of the epitope

Proposed Utility

This Mab can be used to serotype C. fetus strains

Weblink

PubMed Central

External Links

• Link to PolysacDB database