PolysacDB O-polysaccharide 1242

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Brucella abortus W99

[edit] Basic Structure

O-polysaccharide consists of an unbranched linear homopolymer of 10 to 100 α-1,2-linked 4-formamido-4,6-dideoxy-D-mannose (N formylperosamine) residues. The O-polysaccharide is covalently linked to a core oligosaccharide

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Whole B. abortus W99 cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 2C8C4

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA

[edit] Cross-reactivity

This Mab was specific to A strains of Brucella and did not cross-react with Brucella M strain, Y enterocolitica O:9, S-LPSs of S.urbana, Vibrio cholerae and E. coli O:157

[edit] Proposed epitopes

The epitope was proposed to be a pentasaccharide or larger oligosaccharide composed of α1,2-linked D-Rha4NFo and also contained α1,3 linkages

[edit] Proposed Utility

This Mab helped in the epitope strucure elucidation

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database