PolysacDB O-polysaccharide 1238

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Brucella melitensis Rev1

Basic Structure

O-polysaccharide consists of an unbranched linear homopolymer of 10 to 100 α-1,2-linked 4-formamido-4,6-dideoxy-D-mannose (N formylperosamine) residues. The O-polysaccharide is covalently linked to a core oligosaccharide

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole B. melitensis Cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 16A4E7

Antibody type and class

IgG3

Assay System

ELISA

Cross-reactivity

This antibody did not cross-react with S-LPSs of S. urbana, Vibrio cholerae and E. coli O:157, but cross-reacted with S-LPS of Y. enterocolitica O:9 along with Brucella A and M dominant strains

Proposed epitopes

This Mab was directed against the C/Y epitope which basically consists of 2 α1,2-linked D-Rha4NFo residues

Proposed Utility

This Mab helped in the epitope strucure elucidation

Weblink

PubMed Central

External Links

• Link to PolysacDB database