PolysacDB Smooth Lipopolysaccharide 1167

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Smooth Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bordetella parapertusis

Basic Structure

The O-chain of these bacteria was reported as a homopolymer of 1,4-linked 2,3-diacetamido-2,3- dideoxy-α-galacturonic acid. This polymer contains several amidated uronic acids, the number of which varies between strains

Proposed functions

N/A

Antigenic Nature used to produce antibodies

LPS from B. parapertusis

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab PP6

Antibody type and class

IgG3

Assay System

ELISA and ELISA Inhibition assay

Cross-reactivity

This Mab did not react with the B. pertussis LPS but cross-reacted with B. bronchiseptica LPS

Proposed epitopes

The epitope was found to reside on O-chains

Proposed Utility

This Mab can be useful for immunochemical typing and diagnosis of infections due to Bordetella species, and for the structural analysis of their lipopolysaccharides

Weblink

PubMed

External Links

• Link to PolysacDB database