PolysacDB O-polysaccharide 1136

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Actinobacillus pleuropneumoniae serotype 5

Basic Structure

O-chains of LPS are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone

Proposed functions

LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

5Mab-1

Antibody type and class

IgM

Assay System

ELISA inhibition tests

Cross-reactivity

This Mab was specific to serotype 5 strains

Proposed epitopes

The epitope was proposed to consist of of β-1,6-linked D-galactose residues

Proposed Utility

This Mab can be used for specially distinguishing serotype 5 strains

Weblink

?dopt=Abstract' PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database