PolysacDB O-polysaccharide 1123

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Actinobacillus pleuropneumoniae serotype 9

Basic Structure

The structure consists of trisaccharide backbone randomly substituted by N-acetyl-β-D-glucosamine end groups (to the extent of 25%)

Proposed functions

LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus

Antigenic Nature used to produce antibodies

formalin-fixed A. pleuropneumoniae serotype 9 cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

N/A

Assay System

ELISA

Cross-reactivity

This antibody cross-reacted with serotypes 1 and 12. also cross-reacted with deaminated Serotype1 O-PS

Proposed epitopes

The epitope was deduced to contain the terminal nonreducing -D-Glc NAc residues. A second epitope was said to be directed to linear regions of the backbone polymer

Proposed Utility

This antisera not only helped in serotyping analysis but also helped in deducing the epitopes recognized

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database