PolysacDB O-polysaccharide 1119

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Actinobacillus pleuropneumoniae serotype 1 strain Shope 4074

Basic Structure

O chains of LPS of are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone

Proposed functions

LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus

Antigenic Nature used to produce antibodies

formalin-fixed A. pleuropneumoniae serotype 1 cells (strain Shope 4074]

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 3B10

Antibody type and class

IgM

Assay System

ELISA, Rapid Dot ELISA and Slide agglutination test

Cross-reactivity

This antibody cross-reacted with reference strains of serotypes 1, 9 and 11

Proposed epitopes

N/A

Proposed Utility

This Mab may provide reliable specific tools for rapid serological diagnosis of animals infected with serotypes 1, 9 and 11 by inhibition or competition ELISA. Moreover, these mAbs could be useful as a complementary specific reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotypes 1, 9 and 11

Weblink

PubMed

External Links

• Link to PolysacDB database