PolysacDB O-polysaccharide 1118

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Actinobacillus pleuropneumoniae serotype 1 strain Shope 4074

[edit] Basic Structure

O chains of LPS of are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone

[edit] Proposed functions

LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus

[edit] Antigenic Nature used to produce antibodies

formalin-fixed A. pleuropneumoniae serotype 1 cells (strain Shope 4074]

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 11C3

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, Rapid Dot ELISA and Slide agglutination test

[edit] Cross-reactivity

This antibody cross-reacted with reference strains of serotypes 1, 9 and 11

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab may provide reliable specific tools for rapid serological diagnosis of animals infected with serotypes 1, 9 and 11 by inhibition or competition ELISA. Moreover, these mAbs could be useful as a complementary specific reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotypes 1, 9 and 11

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database