PolysacDB O-polysaccharide 1111

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Actinobacillus pleuropneumoniae serotype 5 strain 91-178-2005

Basic Structure

O chains of LPS of are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone

Proposed functions

LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus

Antigenic Nature used to produce antibodies

formalinized whole cell antigen (WCA)

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 6.1E7.E3

Antibody type and class

IgM

Assay System

ELISA, immunoblotting

Cross-reactivity

This antibody specifically reacted with Serotype5 only

Proposed epitopes

N/A

Proposed Utility

This MAb could be useful for serotyping analysis in actinobacillus strains

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database