PolysacDB High molecular weight polysaccharide 1108

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

High molecular weight polysaccharide

Carbohydrate Class

Miscellaneous

Source Microbe

Actinobacillus pleuropneumoniae serotype 4 (field isolate F6)

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

formalin-fixed A. pleuropneumoniae serotype 4 cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 5H7

Antibody type and class

IgM

Assay System

Whole cell ELISA and slide agglutination tests

Cross-reactivity

This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab exhibited 75.8 and 27.3% reactivities with 29 serotype 4 and 12 serotype7 isolates, respectively, and partial binding to serotype 1 and nontypeable isolates

Proposed epitopes

N/A

Proposed Utility

This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7

Weblink

PubMed Central

External Links

• Link to PolysacDB database