PolysacDB Lipopolysaccharide 1083

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Escherichia coli O18A

Basic Structure

The O-polysaccharide part consists of the following residues : -2)α-L-Rhap(1-->6)α-D-Glcp(1-->4)α-D-Galp [branched to β-D-GlcpNAc(1-->3)] (1-->3)α-D-GlcpNAc [branched to α-D-Glcp(1-->6)] (1-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

boiled E. coli 018A bacteria

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab PL13

Antibody type and class

IgM

Assay System

ELISA, immunoblotting and Bacterial agglutination tests, competitive inhibition assays

Cross-reactivity

This Mab was specific to E. coli strain 018A and 018A2 but cross-reacted with S. marcescens 08 LPS

Proposed epitopes

N-acetyl-D-glucosamine seemed to be a part of the epitope

Proposed Utility

N/A

Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC261100 &tool=pmcentrez&rendertype=abstract PubMed Central]

External Links

• Link to PolysacDB database