PolysacDB Lipopolysaccharide 1072

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Escherichia coli Olll:B4

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 5B10

Antibody type and class

IgG2a

Assay System

ELISA, immunoblotting, radioimmunoassay, invivo protection assay

Cross-reactivity

This antibody did not bind to LPS from E. coli 55, an Rc mutant of E. coli 011 1:B4 that lacks both the O-antigen and outer core sugars. 5B10 did not crossreact with LPS from several other E. coli strains

Proposed epitopes

N/A

Proposed Utility

This Mab was able to protect mice from a lethal challenge of E. coli 0111:B4 organisms

Weblink

[http://www.ncbi.nlm.nih.gov/pubmed/3298431 ?dopt=Abstract' PubMed]

External Links

• Link to PolysacDB database