PolysacDB Galactomannan 1043
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Galactomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Aspergillus fumigatus
Basic Structure
Galactomannan is composed of a branched core containing α(1-->2)- and α(1-->6)-linked mannose, with β(1-->5)galactofuranose and/or β(1-->4)galactopyranose moieties linked linearly in side chains terminated by galactofuranose nonreducing end units
Proposed functions
Galactomannan is a major cell wall component in Aspergillusspecies and can also be secreted into the medium as a component of the exoantigen. The galactomannan is immunogenic and polyclonal antibodies against it have been used in antigen detection for the diagnosis of invasive aspergillosis, and in the detection of fungal contamination in foodstuffs
Antigenic Nature used to produce antibodies
cold alkali extract of mycelium
Carrier Name
N/A
Conjugation Method
N/A
Antibodies
Mab 40
Antibody type and class
IgM
Assay System
Indirect Enzyme Immunoassay, immunofluorescence, Preciptin assay
Cross-reactivity
This antibody was cross-reactive with C.albicans
Proposed epitopes
Mannopyranosyl side chain
Proposed Utility
This antibody can be used to detect circulating antigen in the serum of patients with invasive aspergillosis by ELISA inhibition.
