PolysacDB Capsular polysaccharide D 1027
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Capsular polysaccharide D
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Cryptococcus neoformans
Basic Structure
The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
Proposed functions
The capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Sheep erythrocytes
Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
Antibodies
Mab 302
Antibody type and class
IgG1
Assay System
Ouchterlony double immunodiffusion, Phagocytosis assays
Cross-reactivity
This antibody cross-reacted with 2 serotypes- A and D
Proposed epitopes
The reactivity of this antibody required acetylation of the parent polysaccharide. Hence proposed epitopes may be O-acetyl groups
Proposed Utility
MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity
