From DrugPedia: A Wikipedia for Drug discovery

Rv2122c
Name
Phosphoribosyl-ATP pyrophosphatase (hisE)
Identifiers
Swiss Prot	P0A5B1
Genbank	888671
PDB	1Y6X
Chemical data
Formula	C19H15FO5 [1]
Mol. wt.	10243 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	4.3758

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

THOUGHT TO BE INVOLVED IN HISTIDINE BIOSYNTHESIS. Other PDBid: 3C90

Rv2122c, (MTCY261.18), len: 93 aa. Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI. DNA microarrays indicate repression by iron and IdeR|Rv2711 in M. tuberculosis H37Rv (See Rodriguez et al., 2002). Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

[edit] Protein Sequence

>Rv2122c, TB.seq 2380664:2380942 MW:10243 VQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMI SRGLSLDDVYRKL

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q8TC76.1	42	71	28	0.71
sp|Q8NI51.1	26	47	80	2.4
sp|Q6EKJ0.1	36	56	30	6.8
sp|Q86UP8.2	36	56	30	7.3
sp|Q6ZS81.3	20	36	60	7.6

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cytoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.