CarboDB Glucurunoxylomannan 2612
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
Glucurunoxylomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Cryptococcus neoformans serotype A
Basic Structure
The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
Proposed functions
The capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Sheep erythrocytes
Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
Antibodies
Mab 1326
Antibody type and class
IgG1
Assay System
ELISA
Cross-reactivity
This antibody was cross-reactive to serotypes A and D
Proposed epitopes
N/A
Proposed Utility
This monoclonal antibody promoted opsonization of Cryptococcus cells
