CarboDB Lipopolysaccharide 2338

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1 Carbohydrate Name
2 Carbohydrate Class
3 Source Microbe
4 Basic Structure
5 Proposed functions
6 Antigenic Nature used to produce antibodies
7 Carrier Name
8 Conjugation Method
9 Antibodies
10 Antibody type and class
11 Assay System
12 Cross-reactivity
13 Proposed epitopes
14 Proposed Utility
15 Weblink
16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Shigella flexneri serotype 2a

[edit] Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Heat killed cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Antisera raised in monkeys

[edit] Antibody type and class

IgG

[edit] Assay System

ELISA

[edit] Cross-reactivity

The majority of sera from challenged monkeys showed cross-reactivity with almost all flexneri serotypes tested, with 1a, 2b, and Y being recognized most often

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

These results show that either immunization or challenge with the 2a serotype induces cross-reactive antibodies which recognize similar subsets of heterologous serotypes, and suggest that it may be possible to design multivalent vaccines against S. flexneri