CarboDB Core oligosaccharide 2318

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Core oligosaccharide

[edit] Carbohydrate Class

Core oligosaccharide [LPS]

[edit] Source Microbe

Shigella flexneri serotype 1b

[edit] Basic Structure

The core is a single sequence of heptoses and hexoses

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Heat killed cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MASF R3 core-1

[edit] Antibody type and class

IgG2a

[edit] Assay System

immunoblotting, enzyme-linked immunosorbent assay (ELISA), hemagglutination, and coagglutination

[edit] Cross-reactivity

The core-specific antibodies were shown to be specific for the Escherichia coli R3 core, which all S. flexneri LPSs were found to have, except for S. flexneri serotype 6 LPS

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used for detection and identification of shigella flexneri species

[edit] Weblink

PubMed

[edit] External Links

• Link to CarboDB database