CarboDB Lipopolysaccharide 2313

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Shigella flexneri serotype 2a

Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MASF(II:3,4)-1

Antibody type and class

IgG

Assay System

ELISA, agglutination tests

Cross-reactivity

This Mab was specific to 2a LPS

Proposed epitopes

This Mab apparently interact with the α-D-glucose p(1-->4)-α-L-rhamnosyl pIII epitope

Proposed Utility

This Mab can be used for detection and identification of shigella flexneri species

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to CarboDB database