CarboDB O-polysaccharide 2310

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Shigella flexneri serotype 2a strain 2457T

[edit] Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab HYSF2a3

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA and immunoblotting

[edit] Cross-reactivity

HySF2a3 reacted only with 2a and 5a LPSs

[edit] Proposed epitopes

This Mab is likely recognizing an epitope influenced by the presence of a single α-D-glycosyl residue on one of the rhamnose residues

[edit] Proposed Utility

This Mab may have implications for designing a Shigella vaccine that will be protective against related serotypes. This Mab may also be used to study the ultrastructural surface distribution of LPSs on the surface of the bacteria

[edit] Weblink

PubMed Central

[edit] External Links

• Link to CarboDB database