CarboDB Lipopolysaccharide 2305

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Shigella flexneri serotype 2a

Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab A2-1

Antibody type and class

IgG2a

Assay System

ELISA, protection experiments

Cross-reactivity

This Mab cross-reacted with S. flexneri serotype X, Y, 5a, 5b, 2a, 2b, 1a, 3a

Proposed epitopes

This Mab recognized the pentasaccharide L-rhamnose-L-rhamnose-α-D-glucose-L-rhamnose-N-acetyl-D-glucosamine

Proposed Utility

This Mab showed invivo protection

Weblink

PubMed

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to CarboDB database