CarboDB Core oligosaccharide 2292
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Core oligosaccharide
Carbohydrate Class
Core oligosaccharide [LPS]
Source Microbe
Shigeila sonnei serotype D
Basic Structure
Lipopolysaccharide (LPS) molecules consist of three structural regions: a lipid A region, which anchors the molecule in the bacterial outer membrane; an intermediate core region; and a distal, serotype-specific O-polysaccharide chain (O chain or O-antigen). Whereas the chemical composition and structure of 0 chains are highly variable, the core moiety is more conserved. Seven types of LPS core structures, namely, Ra, Ri to R4, K-12, and B, have been found in members of the family Enterobacteriaceae
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Heat killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab Sh9R
Antibody type and class
IgM
Assay System
ELISA and immunoblotting
Cross-reactivity
only strains reported to have LPS molecules with an R1-type core structure were recognized, namely, S. sonnei, S. boydii type 3, S. flexneri type 6, a control E. coli R1 strain (HF4704), and an E. coli 09 isolate
Proposed epitopes
Terminal hexose residues may form an important part of the epitope
Proposed Utility
This Mab has been used to analyze clinical isolates and a hybrid Salmonella typhi strain for their expression of the corresponding LPS moieties. In addition to their use in the screening of candidate vaccine strains, the new MAb provide a powerful tool for epidemiological and phylogenetic studies of natural enterobacterial populations
