CarboDB O-polysaccharide 2280
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
O-polysaccharide
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Shigella flexneri serotype Y
Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MASF B
Antibody type and class
IgM
Assay System
ELISA
Cross-reactivity
The MASF B antibody reacted with all S. flexneri LPSs tested except 4bR, the rough mutant
Proposed epitopes
α-L-Rhap-1-->2-α-L-Rha residues seemed to be the part of the epitope
Proposed Utility
This Mab may prove to be valuable reagents in the studies of protective immunity against Shigella bacteria
