CarboDB Y O-polysaccharide 2270

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Y O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Shigella flexneri

Basic Structure

The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain

Proposed functions

N/A

Antigenic Nature used to produce antibodies

heat-killed S. flexnerf bacteria serotype Y

Carrier Name

nil

Conjugation Method

nil

Antibodies

Antisera

Antibody type and class

N/A

Assay System

ELISA, FARR assay

Cross-reactivity

The polyclonal rabbit anti-group antigen 3.4 antibodies reacted with the lb, 2a, 3b, 4a. 4b, and Y LPS. They did not bind to1a and 5a. In glycoconjugate ELISA's it bound to all saccharides especially abcd- and decasaccharide- BSA antigens

Proposed epitopes

Antigen 3,4 seemed to be the epitope

Proposed Utility

This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide

Weblink

PubMed

External Links

• IEDB Epitopic Detail

• Link to CarboDB database