CarboDB LDN-DF 2239
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
LDN-DF
Carbohydrate Class
Miscellaneous
Source Microbe
Schistosoma mansoni
Basic Structure
This carbohydrate consists of N-linked glycans containing GalNAc-β-1-->4[Fucα1-->2Fucα 1-->3]GLcNAc
Proposed functions
These carbohydrate structures are mainly involved in immune evasion
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Bovine serum albumin
Conjugation Method
The spacer linked oligosaccharides were converted to their N-hydroxysuccinimido-ester complexes and conjugated to amino groups on BSA
Antibodies
Mab 290-2D9-A
Antibody type and class
IgM
Assay System
ELISA, indirect immunfluorescence and surface plasmon resonance
Cross-reactivity
This Mab was highly specific and did not show cross-reactivity to other carbohydratge epitopes
Proposed epitopes
This Mab was directed to epitopes mainly present on the excretory system, on miracidia, and on the whole cercariae
Proposed Utility
This Mab may lead to a better understanding of the function of glycans
