CarboDB LDN-DF 2238

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

LDN-DF

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Schistosoma mansoni

[edit] Basic Structure

This carbohydrate consists of N-linked glycans containing GalNAc-β-1-->4[Fucα1-->2Fucα 1-->3]GLcNAc

[edit] Proposed functions

These carbohydrate structures are mainly involved in immune evasion

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Bovine serum albumin

[edit] Conjugation Method

The spacer linked oligosaccharides were converted to their N-hydroxysuccinimido-ester complexes and conjugated to amino groups on BSA

[edit] Antibodies

Mab 176-3A7

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, indirect immunfluorescence and surface plasmon resonance

[edit] Cross-reactivity

This Mab was highly specific and did not show cross-reactivity to other carbohydratge epitopes

[edit] Proposed epitopes

This Mab was directed to epitopes mainly present on the excretory system, on miracidia, and on the whole cercariae

[edit] Proposed Utility

This Mab may lead to a better understanding of the function of glycans

[edit] Weblink

PubMed

[edit] External Links

• Link to CarboDB database