CarboDB Core oligosaccharide 2216

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Salmonella choleraesuis SN57 [Ra]

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MASC1-MM3

Antibody type and class

IgM

Assay System

enzyme immunoassay, immunoblotting

Cross-reactivity

This Mab cross-reacted with with six different Salmonella core chemotypes S, Ra, Rb1, Rb2, Rb3, Rc and Rd1, the R2 core of Escherichia coli and a variety of smooth LPS

Proposed epitopes

The terminal disaccharide L-α-D-Hep1-->7-L-α-D-Hep1-O-me seemed to be the immunodominant epitope

Proposed Utility

This Mab would help elucidate the LPS core domain structure

Weblink

PubMed

External Links

• Link to CarboDB database