CarboDB Capsular Vi polysaccharide 2214

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular Vi polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Salmonella typhi

Basic Structure

The salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid

Proposed functions

It is an important virulence factor. The Vi capsule shields the bacteria against phagocytosis by its surface negative charge properties and by covering cell-envelope components sensitive to serum opsonins

Antigenic Nature used to produce antibodies

Heat killed bacteria and purified Vi polysaccharide

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MATy-V5

Antibody type and class

IgM

Assay System

inhibition enzyme immunoassay

Cross-reactivity

This Mab was specific to Vi antigen

Proposed epitopes

N/A

Proposed Utility

This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to CarboDB database