CarboDB Capsular polysaccharide 1821
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Neisseria meningitidis group C
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Tetanus toxoid
Conjugation Method
The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days
Antibodies
Mab C2/181.7
Antibody type and class
IgG1
Assay System
ELISA
Cross-reactivity
This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide but did not react with E. coli K92 capsular polysaccharide
Proposed epitopes
N/A
Proposed Utility
This Mab can be used for studying the capsular polysaccharide immunogenicity
