CarboDB N-propionylated group B meningococcal polysaccharide 1789
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
N-propionylated group B meningococcal polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Neisseria meningitidis
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Tetanus toxoid
Conjugation Method
N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37C for 5 days
Antibodies
Mab 13A8
Antibody type and class
IgG1
Assay System
ELISA, bactericidal assays
Cross-reactivity
N/A
Proposed epitopes
The epitope was located only on extended helical segments of the polysaccharide
Proposed Utility
This Mab would help in the elucidation of the capsular polysaccharide structure
