CarboDB Glycopeptidolipid antigen 1680
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glycopeptidolipid antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium avium complex serovar 9
[edit] Basic Structure
This antigen is composed of a glycosylated lipopeptide core, fatty acyl-D-phenylalanine-D-allothreonine-D-alanine-L-alaninyl-O-(3,4-di-O-methyl-α-L-rhamnopyranoside), to which a haptenic oligosaccharide is linked at the threonine substituent
[edit] Proposed functions
This oligosaccharide unit is the source of the dominant immunogenicity of members of the M. avium complex, i.e., their characteristic agglutinability and type specificity
[edit] Antigenic Nature used to produce antibodies
whole washed heat-killed bacteria
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab B192
[edit] Antibody type and class
IgG2b
[edit] Assay System
ELISA, Inhibition assays, dot blot
[edit] Cross-reactivity
This antibody cross-reacted with Whole cells of serovar 9 and acetylated-GPL-9 and it was highly cross-reactive for other serovars and their GPLs
[edit] Proposed epitopes
4-O-acetyl-2,3-di-O-methyl-α-L-fucopyranosyl-(1-->4)-β-D-glucuronopyranosyl residues seemed to be the part of the epitope
[edit] Proposed Utility
This Mab can be used for the identification and classification of M. avium isolates. This Mab can be applied directly to bacterial cultures, thus allowing easy, rapid identification of at least half of the M. avium isolates encountered in the clinical laboratory
