CarboDB Glycopeptidolipid antigen 1668

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Glycopeptidolipid antigen

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium avium complex serovar 1

Basic Structure

This antigen is composed of a glycosylated lipopeptide core, fatty acyl-D-phenylalanine-D-allothreonine-D-alanine-L-alaninyl-O-(3,4-di-O-methyl-α-L-rhamnopyranoside), to which a haptenic oligosaccharide is linked at the threonine substituent

Proposed functions

This oligosaccharide unit is the source of the dominant immunogenicity of members of the M. avium complex, i.e., their characteristic agglutinability and type specificity

Antigenic Nature used to produce antibodies

whole cells combined with whole unfractionated lipid

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 3F6

Antibody type and class

IgG3

Assay System

ELISA, Inhibition assays, dot blot

Cross-reactivity

This antibody cross-reacted with whole cells of serovar 1 and acetylated-GPL-1

Proposed epitopes

Distal O-acetyl-α-L-rhamnopyranosyl residues seemed to be a part of the epitope

Proposed Utility

This Mab can be used for the identification and classification of M. avium isolates. This Mab can be applied directly to bacterial cultures, thus allowing easy, rapid identification of at least half of the M. avium isolates encountered in the clinical laboratory

Weblink

PubMed Central

External Links

• IEDB Epitopic Detail

• Link to CarboDB database