CarboDB Capsular polysaccharide 500 antigen 1376

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide 500 antigen

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Cryptosporidium parvum

Basic Structure

CPS-500 is a chloroform-extractable glycolipid

Proposed functions

CPS-500 is a candidate target antigen for active or passive immunization against cryptosporidiosis

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 18.44

Antibody type and class

IgG3

Assay System

ELISA, immunoblotting

Cross-reactivity

N/A

Proposed epitopes

the neutralization-sensitive epitope recognized by MAb 18.44 is dependent on terminal β-D-mannopyranosyl residues

Proposed Utility

MAb 18.44 neutralizes the infectivity of both sporozoites and merozoites and to significantly reduce C. parvum infection in oocyst-challenged mice when coadministered with other neutralizing Mab

Weblink

PubMed

External Links

• Link to CarboDB database