CarboDB Core oligosaccharide 1232

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Brucella abortus S19

Basic Structure

Core oligosaccharide is composed of mannose, glucose, 2-amino-2,6-dideoxyglucose (quinovosamine), 2-amino-2-deoxyglucose (GlcN),3-deoxy-D-manno-2-octulosonic acid (KDO), and unidentified sugars. The core is linked to the lipid A, which in contrast to most LPS studied, contains both GlcN and 2,3- diamino-2,3-dideoxyglucose (GlcN3N) as backbone sugars and amide- and ester-linked long-chain saturated (C16:0 to C18:0) and hydroxylated (3-OH-C12:0, to 29-OH-C30:0) fatty acids

Proposed functions

N/A

Antigenic Nature used to produce antibodies

acetone-killed B. abortus S19 cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab Baro-1

Antibody type and class

IgG3

Assay System

Enzyme Immunoassay,immunoblotting

Cross-reactivity

Baro1 Mab showed cross-reactivity against B. melitiensis, B. canis and B. ovis LPS. Did not cross-react wirth S. coli and S. minnesota

Proposed epitopes

N/A

Proposed Utility

This Mab may help in the elucidation of epitopic distribution of Brucella abortus LPS

Weblink

PubMed Central

External Links

• Link to CarboDB database