CarboDB Lipopolysaccharide 1183

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bordetella pertusis 18530

Basic Structure

N/A

Proposed functions

The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties

Antigenic Nature used to produce antibodies

B. pertussis 18530 LPS

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 6-4-H6

Antibody type and class

IgG3

Assay System

ELISA

Cross-reactivity

This antibody cross-reacted with delipidated polysaccharide fragments (PS-1 and PS-2). did not react with LPS prepared from B. parapertussis and B. bronchiseptica. No cross-reactions were observed with strains of Branhamella catarrhalis, Neisseria meningitidis, Streptococcus miteor, Haemophilus influenza, or Legionella pneumophila

Proposed epitopes

N/A

Proposed Utility

This Mab might be useful for the detection of soluble antigens and whole bacteria in clinical samples and for studies of the immunochemical structure of B. pertussis LPS.

Weblink

PubMed Central

External Links

• Link to CarboDB database