CarboDB Lipoologosaccharide band A of the LPS 1181
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipoologosaccharide band A of the LPS
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Bordetella pertusis 325
Basic Structure
N/A
Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
Antigenic Nature used to produce antibodies
partially purified preparations of fimbriae from B. pertussis 325
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab E8D8B1
Antibody type and class
IgG3
Assay System
Immunoblotting
Cross-reactivity
Four strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae
Proposed epitopes
N/A
Proposed Utility
This Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS.
