CarboDB Lipoologosaccharide band A of the LPS 1173

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoologosaccharide band A of the LPS

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bordetella pertusis 9340

Basic Structure

B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B

Proposed functions

The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties

Antigenic Nature used to produce antibodies

N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab BL-3

Antibody type and class

IgM

Assay System

ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA

Cross-reactivity

This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype

Proposed epitopes

N/A

Proposed Utility

This Mab was capable of inducing bactericidal activity in uitro.

Weblink

PubMed

External Links

• Link to CarboDB database