CarboDB Capsular polysaccharides K5 1039
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
Capsular polysaccharides K5
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Escherichia coli
Basic Structure
Capsular polysacchirides K5 is disaccharide with repeating unit 4-β-GlcUA(1-->4)-α-GlcNAc
Proposed functions
Capsular polysaccharides are responsible for pathogen`s virulence
Antigenic Nature used to produce antibodies
Whole formalinized E.coli cells.
Carrier Name
N/A
Conjugation Method
N/A
Antibodies
Mab 865
Antibody type and class
IgM
Assay System
Indirect ELISA, Immunoblot analysis
Cross-reactivity
This antibody was cross-reactive with ECA of E.coli and S.typhimurium strains.
Proposed epitopes
4-β-GlcUA(1-->4)-α-GlcNAc
Proposed Utility
Reaction pattern of Mab with whole cell bacteria indicate that ECA and outer core in encapsulated bacteria are not readily accessible to antibodies.This suggests that these common envelop structures may not be useful antigens for vaccine development.
