Structural annotation of Rv2753c (dihydrodipicolinate synthase)
From DrugPedia: A Wikipedia for Drug discovery
| Structural annotation of Rv2753c (dihydrodipicolinate synthase)
| |
| Name | |
| Dihydrodipicolinate Synthase | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 30,858 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.57 |
Contents |
General
dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.
This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.
Amino Acid Sequence of Rv2753c
>Rv2753c, TB.seq 3066222:3067121 MW:30827 VTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|Q9BXD5 | 28 | 46.33 | 300 | 3.00E-023 |
| sp|Q86XE5 | 26.57 | 46.15 | 286 | 4.00E-022 |
| sp|Q9UG63 | 26.49 | 37.75 | 151 | 0.45 |
| sp|O14556 | 22.09 | 50 | 86 | 2 |
| sp|Q7Z7B0 | 27.69 | 44.62 | 65 | 2.7 |
Antigens
No Hit Found in AntigenDB Database.
No Hit Found in IEDB Database.
No Hit Found in MHCBN Database.
No Hit Found in BciPep Database.
Haptens
Epitopes
B-Cell Epitopes
MHC class I restricted T cell epitopes
CTL Epitopes
MHC Binder
Class-I Binder
Result predicted by nhlapred
| Epitope | No of Alleles |
| VPIEPDTIR | 15 |
| TPFSGDGSL | 14 |
| TLSKAGLRL | 13 |
| IEPDTIRAL | 13 |
| GTYDTAHSI | 13 |
| DDALNLPWL | 11 |
| GFISVIAHL | 10 |
| GATGFISVI | 10 |
| ATPEQIDAL | 10 |
| YDTAHSIRL | 9 |
| GDIATARKI | 9 |
| AVLEAVGDR | 9 |
| ASHPNIVGV | 9 |
| QRGLQAHFT | 7 |
| GLQAHFTAV | 7 |
| AVGDRARVI | 7 |
| YSGDDALNL | 6 |
| VGFDVAARL | 6 |
| QLRELLSAF | 6 |
| TAVADATEL | 5 |
| TAARLANHL | 5 |
| LLRAVLEAV | 5 |
| GEKIELLRA | 5 |
| DTATAARLA | 5 |
| AAGQLRELL | 5 |
| TDGEKIELL | 4 |
| QAHFTAVAD | 4 |
| MSRLGGVTL | 4 |
| LDTATAARL | 4 |
| HPNIVGVKD | 4 |
| GVKDAKADL | 4 |
| DGEKIELLR | 4 |
| KIELLRAVL | 3 |
| HSIRLAKAC | 3 |
| GSGDIATAR | 3 |
| AHLAAGQLR | 3 |
| PTTTDGEKI | 2 |
| IAHLAAGQL | 2 |
| DLHSGAQIM | |
| 2 |
Result predicted by IEDB
| Epitope | No of Alleles |
| RVIAGAGTY | 12 |
| IMADTGLAY | 11 |
| MADTGLAYY | 7 |
| GLQAHFTAV | 7 |
| ATELPMLLY | 6 |
| ALASHPNIV | 6 |
| GTYDTAHSI | 5 |
| GLLVVTPYY | 5 |
| MSRLGGVTL | 4 |
| LLRAVLEAV | 4 |
| WLAMGATGF | 3 |
| QLRELLSAF | 3 |
| RALASHPNI | 2 |
| LLTAMVTPF | 2 |
| KINIAVAPL | 2 |
| GFISVIAHL | 2 |
Class-II Binder
Alergen Protein
Non Allergen Predicted by AlgPred Server
